After Wilson admitted the forgery to Tritter, he once again refused to cooperate with Tritter after House saved yet another patient no-one else could.

He lied to Michael Tritter when House forged Wilson's signature on Wilson's prescription pad.

He was the only board member to vote against firing House in order to satisfy Edward Vogler, which cost him his spot on the board and almost cost him his job.

Wilson has gone to extreme lengths to protect and support House, as well as enable House's abusive and manipulative behavior: It was also Wilson's idea not to tell House that he was right about Richard McNeil suffering from Addison's disease. For example, although Cuddy proposed the bet to House that he give up Vicodin for a week in order to reduce his clinic duty, it was Wilson's idea. Although he cares deeply for House, he often goes behind his back in attempts to help him.

He has been treated for clinical depression. He does seem to suggest to last girlfriend Sam (also his first wife) that he wants a child with her in Season 7, as when she says she should get a puppy, he replies, 'Or pregnant.' He proposed to her in the following episode, but it resulted in her leaving him. Wilson states in Season 1 that he has no children.

He has had a relationship with one of his terminally ill patients, and dated one of House's rejected applicants, Amber Volakis until her untimely death. He has been married and divorced three times (his first wife was Sam Carr, the second wife was Bonnie Wilson, the third Julie Wilson). Wilson acts as House's conscience, sounding board, and the enabler of his abusive personality. Gregory House's sole good friend up until his resignation from the hospital and (probable, due to his refusal to continue treatment) eventual death from Thymoma, which he was officially diagnosed with in the Season 8 episode, Body and Soul. He was the Head of Oncology at Princeton-Plainsboro Teaching Hospital and also Dr. James Evan Wilson was a major character on House from the first season until the end of the series. ' He paid for your lunch, liked monster trucks, and was your conscience.' ―Kutner reminding House what Wilson did for him in Not Cancer

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